Menopause
The permanent cessation of menstruation due to ovarian follicle depletion, defined as 12 consecutive months without a menstrual period.
The perimenopause transition can begin years before menopause. Estrogen decline causes vasomotor symptoms, vaginal atrophy, sleep disturbance, and accelerated bone loss. HRT is effective but has risks in certain populations.
(Placeholder study content — expanded in the content build step.)
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